Enhanced Bioavailability of Digoxin by γ-Cyclodextrin Complexation : Evaluation for Sublingual and Oral Administrations in Humans
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چکیده
منابع مشابه
Enhanced dissolution and oral bioavailability of coenzyme Q10 in dogs obtained by inclusion complexation with γ-cyclodextrin
Purpose: The solubility of coenzyme Q10 (CoQ10) in water is extremely low, resulting in a low oral bioavailability. In this study, we attempted to improve the low dissolution and bioavailability of CoQ10, by means of the complexation with natural α-, βand γ-cyclodextrins (CyDs) and 2-hydroxypropyl-β-CyD (HP-β-CyD). Methods: The complexation of CoQ10 with CyDs was studied by the solubility metho...
متن کاملEnhancement of Naringenin Bioavailability by Complexation with Hydroxypropoyl-β-Cyclodextrin
The abundant flavonoid aglycone, naringenin, which is responsible for the bitter taste in grapefruits, has been shown to possess hypolipidemic and anti-inflammatory effects both in vitro and in vivo. Recently, our group demonstrated that naringenin inhibits hepatitis C virus (HCV) production, while others demonstrated its potential in the treatment of hyperlipidemia and diabetes. However, narin...
متن کاملEnhancement of Oral Bioavailability of Functional Ingredients by Complexation with Cyclodextrin
Natural lipophilic bioactives that possess human health benefits, such as coenzyme Q10 (CoQ10) and R-α-lipoic acid (RALA), often have undesirable characteristics that limit their use as nutraceuticals and cosmeceuticals. These bioactives are usually unstable against oxygen, ultraviolet light, low pH and heat. Furthermore, their watersolubility is low because of their hydrophobic nature or insta...
متن کاملThe hydroxypropyl–β-cyclodextrin complexation of toltrazuril for enhancing bioavailability
Introduction Toltrazuril (Tol) is used to prevent and combat coccidiosis. However, its low aqueous solubility and poor oral bioavailability limit clinical application. Methods To overcome the shortcomings, toltrazuril-hydroxypropyl-β-cyclodextrin inclusion complex (Tol-HP-β-CD) was prepared and characterized. The comparative plasma disposition kinetics of Tol was analyzed after a single orall...
متن کاملComplexation of Z-ligustilide with hydroxypropyl-β-cyclodextrin to improve stability and oral bioavailability.
To improve the stability and oral bioavailability of Z-ligustilide (LIG), the inclusion complex of LIG with hydroxypropyl- β-cyclodextrin (HP-β-CD) was prepared by the kneading method and characterized by UV-Vis spectroscopy, differential thermal analysis (DTA) and Fourier transform infrared (FTIR) spectroscopy. LIG is capable of forming an inclusion complex with HP-b-CD and the stoichiometry o...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1989
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.109.10_778